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Diflucan® (fluconazole) Information

Diflucan® (generic is fluconazole) is used to treat and prevent fungal infections. These include yeast infections of the vagina, mouth, throat, esophagus, abdomen, lungs, other organs and blood. The medication also is used to treat a fungus-caused infection of the brain called meningitis.

Diflucan® may be taken by patients with a compromised immune system. In patients who are treated with radiation therapy or chemotherapy before a bone marrow transplant to lower the chance they will reject the transplant, Diflucan® is used to prevent infection.

The drug is in a class of antifungal medications called triazoles, which retard the growth of fungi that cause infections. It works by disrupting the formation of the fungal cell membrane. This leads to the cell contents leaking out of the cell and results in cell death.

Diflucan® Dosage Information

The size of the dose of Diflucan® prescribed depends upon the condition being treated. A low dose of Diflucan® is used to treat vaginal yeast infections.

The medication, which is usually taken once a day, is swallowed either in the form of a tablet or a liquid suspension. The fluid form should be shaken to be sure it is well mixed before taking it. The length of treatment with the drug depends upon the condition being treated and how well the patient responds.

Tablets come in 50 mg, 100 mg, 150 mg, and 200 mg form. The liquid form, when reconstituted, comes in 10 mg/mL and 40 mg/mL amounts.

Important Patient Information

Diflucan® interacts adversely with a number of medications, so it is important to tell your doctor all the medications you are taking. Those of special concern are:

  • Diabetes medications
  • Blood pressure medicines
  • Blood thinners
  • Drugs to prevent rejection of organ transplants
  • Tuberculosis drugs
  • Asthma drugs
  • Heartburn drugs
  • Certain heart rhythm medicines
  • Some antidepressants
  • Other drugs to treat psychiatric illness
  • Fungal infection drugs
  • Certain antibiotics
  • Some cancer therapies
  • Certain chronic pain drugs
  • Some antimalarial drugs
  • Lipid-lowering drugs
  • Some nonsteroidal anti-inflammatory drugs
  • Prednisone
  • Certain antiviral drugs to treat HIV
  • Vitamin A

It is important to tell your doctor if you are pregnant or planning to become pregnant.

Diflucan® and Pregnancy

Treatment with high doses of Diflucan® (400 mg to 800 mg per day) during the first trimester of pregnancy may be linked to a rare set of birth defects in newborns, according to a U.S. Food and Drug Administration (FDA) announcement issued Aug. 3, 2011. The regular low single dose of the drug (150 mg) for vaginal yeast infections does not seem to pose a risk, the agency said.

Because of this, the FDA changed the pregnancy category of the drug from category C to category D. However, the pregnancy category for a single low dose of the medication is still a category C.

Pregnancy category D means that there is clear evidence of a risk to the human fetus. This is in contrast to category C that means there are possible animal studies showing harm to the fetus, but no human data to show any danger.

For more information about a possible legal case, contact our Diflucan® birth defect lawyers.

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